Research network

Meet the researchers in the SepsisNet network. Together we are committed to strengthening scientific research on sepsis and sharing knowledge.

The SepsisNet network brings together researchers who are committed to better understanding sepsis and improving care for patients. On this page you can discover who is active in the network, what their expertise is and which studies they are working on. By making our knowledge, experience and research interests visible, we encourage collaboration and new connections.

Are you a researcher in the network? Introduce yourself and explore opportunities to advance sepsis research together.

Researchers in the network

Portretfoto van Dr. C.C.M. (Charlotte) Schaap

Dr. C.C.M. (Charlotte) Schaap

Acute Internal Medicine Physician

Portretfoto van Dr. G.H. (Geert) Groeneveld

Dr. G.H. (Geert) Groeneveld

Acute Internal Medicine and Infectious Diseases Physician

Portretfoto van Dr. H. (Hessel) Peters-Sengers

Dr. H. (Hessel) Peters-Sengers

Epidemiologist

Portretfoto van Dr. J. (Jaap) ten Oever

Dr. J. (Jaap) ten Oever

Infectious Diseases Physician

Portretfoto van Dr. J.A. (Jeroen) Schouten

Dr. J.A. (Jeroen) Schouten

Intensivist

Portretfoto van Dr. L. (Lonneke) Van Vught

Dr. L. (Lonneke) Van Vught

General Practitioner and Assistant Professor

Portretfoto van Dr. M. (Matthijs) Kox

Dr. M. (Matthijs) Kox

Senior Researcher, Intensive Care

Portretfoto van Dr. N. (Noortje) Zelis

Dr. N. (Noortje) Zelis

Acute Internal Medicine Physician

Portretfoto van Dr. P.M. (Patricia) Stassen

Dr. P.M. (Patricia) Stassen

Acute Internal Medicine Physician

Portretfoto van Dr. S. (Sanne) Ter Horst

Dr. S. (Sanne) Ter Horst

Postdoctoral Researcher, Acute Internal Medicine

Portretfoto van Prof. dr. (Hjalmar) Bouma

Prof. dr. (Hjalmar) Bouma

Acute Internal Medicine Physician and Clinical Pharmacologist

Portretfoto van Prof. dr. (Karin) Kaasjager

Prof. dr. (Karin) Kaasjager

Acute Internal Medicine Physician

Portretfoto van Prof. dr. (Tom) van der Poll

Prof. dr. (Tom) van der Poll

Infectious Diseases Physician

Portretfoto van Prof. dr. A.R.H. (Arthur) van Zanten

Prof. dr. A.R.H. (Arthur) van Zanten

Internist-Intensivist

Portretfoto van Prof. dr. L.D.J. (Lieuwe) Bos

Prof. dr. L.D.J. (Lieuwe) Bos

Pulmonologist-Intensivist

Portretfoto van Prof. dr. M (Matijs) van Meurs

Prof. dr. M (Matijs) van Meurs

Intensivist

Portretfoto van Prof. Dr. M.G. (Mihai) Netea

Prof. Dr. M.G. (Mihai) Netea

Infectious Diseases Physician

Portretfoto van Prof. dr. O.L. (Olaf) Cremer

Prof. dr. O.L. (Olaf) Cremer

Professor of Intensive Care Medicine

Portretfoto van Prof. dr. R.P. (Roderick) Venekamp

Prof. dr. R.P. (Roderick) Venekamp

Professor of General Practice

Portretfoto van Prof. dr. W.J. (Joost) Wiersinga

Prof. dr. W.J. (Joost) Wiersinga

Infectious Diseases Physician

Publications from the network

  1. Flagellin enhances innate immune responses in human airway epithelium during bacterial infection.
    Li X, Sachet L, Cayet D, …, van der Poll T
    Infect Immun · 2026 Nov 6 SepsisNet
  2. Vasopressors as immunomodulators: a hidden axis in septic shock.
    Leisman DE, Kox M, Pickkers P
    Intensive Care Med · 2026 Nov 5 SepsisNet
  3. TREM-1 in Sepsis and Septic Shock: From Pathophysiology to Precision Immunomodulation.
    Evrard B, Van Der Poll T, Chousterman B et al.
    Semin Respir Crit Care Med · 2026 Oct 29 SepsisNet
  4. A single-cell atlas of human neutrophils reveals neutrophil heterogeneity across health and disease.
    Zheng H, Maestri E, Moore AR, …, van der Poll T, Bouma HR
    Nat Immunol · 2026 Nov SepsisNet
  5. Virtual Wards for Acute Care Patients: A Scoping Review.
    van Baar de Knegt SME, Zelis N, Kaasjager KAH, …, Stassen PM
    J Gen Intern Med · 2026 Oct 13 SepsisNet

Source: PubMed, updated automatically.

Show full publication list
  1. Flagellin enhances innate immune responses in human airway epithelium during bacterial infection.
    Li X, Sachet L, Cayet D, …, van der Poll T
    Infect Immun · 2026 Nov 6 SepsisNet
  2. Vasopressors as immunomodulators: a hidden axis in septic shock.
    Leisman DE, Kox M, Pickkers P
    Intensive Care Med · 2026 Nov 5 SepsisNet
  3. TREM-1 in Sepsis and Septic Shock: From Pathophysiology to Precision Immunomodulation.
    Evrard B, Van Der Poll T, Chousterman B et al.
    Semin Respir Crit Care Med · 2026 Oct 29 SepsisNet
  4. A single-cell atlas of human neutrophils reveals neutrophil heterogeneity across health and disease.
    Zheng H, Maestri E, Moore AR, …, van der Poll T, Bouma HR
    Nat Immunol · 2026 Nov SepsisNet
  5. Virtual Wards for Acute Care Patients: A Scoping Review.
    van Baar de Knegt SME, Zelis N, Kaasjager KAH, …, Stassen PM
    J Gen Intern Med · 2026 Oct 13 SepsisNet
  6. Am I receiving good care? A qualitative study exploring the moral experiences of MDRO carriers in Dutch hospitals and nursing homes.
    Damsté C, Oerlemans A, Rump B, …, Ten Oever J
    J Hosp Infect · 2026 Oct 13 SepsisNet
  7. Plasma mitochondrial-associated proteins scale with illness severity and predict outcome in suspected sepsis.
    Meems CJ, van Beuningen FE, Coenen BA, …, Ter Horst S, Bouma HR
    Crit Care · 2026 Aug 29 SepsisNet
  8. Implications of different SOFA score variants for outcome prediction in emergency department patients with an infection: a multicenter cohort study.
    van der Aart TJ, Hincapié-Osorno C, Arango-Gil IS, …, Ten Oever J, Bouma HR
    Int J Infect Dis · 2026 Sep 25 SepsisNet
  9. Proteins as Regulators of Metabolic Changes in Sepsis: Alterations in Body Fluids, Immune Cells, and Organs through the Eyes of Proteomics.
    Leite GGF, Dal-Pizzol F, van der Poll T et al.
    J Proteome Res · 2026 Sep 4 SepsisNet
  10. Is home-based management feasible for COVID-19 patients requiring oxygen therapy? A participatory action study and cost analysis.
    Boeijen JA, van de Pol AC, Smit K, …, Venekamp R
    BMJ Open · 2026 Sep 3 SepsisNet
  11. Post-Sepsis Syndrome: From Pathogenesis Toward Novel Management Strategies.
    Schouten D, Wiersinga WJ, van Vught L
    Crit Care Clin · 2026 Oct SepsisNet
  12. Sepsis, endemic and emerging infectious diseases: converging concepts and clinical implications.
    Salomão R, Leite GGF, Salomão MC, …, van der Poll T
    Lancet Infect Dis · 2026 Sep 2 SepsisNet
  13. Acute kidney injury in Staphylococcus aureus bacteraemia: a multicentre cohort study of incidence, timing, recovery and associations with antibiotic treatment.
    Sinkeler FS, Kouijzer IJE, Jager NGL, …, Ten Oever J
    J Antimicrob Chemother · 2026 Sep 1 SepsisNet
  14. Adding age and sex to improve adverse outcome prediction in suspected infection: validation of a modified National Early Warning Score in the emergency department.
    Turgman O, Boelens CM, Schinkel M, …, Wiersinga WJ, van der Poll T
    Eur J Emerg Med · 2026 Oct 1 SepsisNet
  15. Testing knowledge boundaries: adversarial evaluation of large language models for antimicrobial stewardship.
    Abejez-Arrizabalaga Á, Pellejero-Sagastizabal G, Aznar-Gimeno R, …, Schouten J
    Clin Microbiol Infect · 2026 Aug 22 SepsisNet
  16. Antimicrobial stewardship in practice: determinants of prescription behaviour and developing interventions to improve surgical prophylaxis in a Rwandan tertiary hospital-a mixed methods study using the behaviour change wheel.
    Theunissen C, Muremba MF, Bitunguhari L, …, Schouten J
    Antimicrob Resist Infect Control · 2026 Aug 17 SepsisNet
  17. Artificial intelligence and antimicrobial stewardship: From clinical decision support to public health action-On behalf of APUA.
    Ghafur A, Nagao M, Kanj SS, …, Schouten J
    J Glob Antimicrob Resist · 2026 Sep SepsisNet
  18. Interobserver Agreement for Classifying Infections in Emergency Department Patients Using Modified Centers for Disease Control and Prevention Criteria.
    Turgman O, Reijnders E, Joosten SCM, …, Peters-Sengers H, van der Poll T, Wiersinga WJ
    Open Forum Infect Dis · 2026 Aug SepsisNet
  19. Identifying emergency department patients at risk of diagnostic discordance between the presumptive emergency department diagnosis and the adjudicated discharge diagnosis: The independent role of frailty.
    van Knippenberg YMW, Föhse K, Schaap CCM, …, Netea MG, Ten Oever J
    Int J Infect Dis · 2026 Oct SepsisNet
  20. Routine Serial Follow-up Blood Cultures After a Negative Result Within 48 Hours of Methicillin-susceptible Staphylococcus aureus Bacteremia: Low Yield, High Cost.
    Hendriks MMC, Kamps EHHM, Norberhuis C, …, Netea MG, Ten Oever J
    Clin Infect Dis · 2026 Oct 28 SepsisNet
  21. Real-world clinical evaluation of the Inflammatix TriVerity test for sepsis at the emergency department: an Acutelines study.
    Ter Voert MA, Lu J, Hincapié-Osorno C, …, Ter Horst S, Bouma HR
    Intern Emerg Med · 2026 Jul 8 SepsisNet
  22. Development and validation of a diagnostic model for late-onset neonatal sepsis using the haematological profile: a retrospective cohort study.
    Hyde E, Schouten J, Saker J et al.
    Intensive Care Med Paediatr Neonatal · 2026 SepsisNet
  23. Endothelial glycocalyx injury in bacterial bloodstream infection: biological determinants and association with host response aberrations.
    Wang H, Butler JM, Michels EHA, …, Cremer OL, Peters-Sengers H, van der Poll T
    Front Cell Infect Microbiol · 2026 SepsisNet
  24. Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia.
    Staphylococcus aureus Network Adaptive Platform (SNAP) Trial Group, Lee TC, Barina LA, …, Ten Oever J
    N Engl J Med · 2026 Jun 18 SepsisNet
  25. Evaluating a new partner management strategy for bacterial sexually transmitted infections after a change in 2020 in Amsterdam, the Netherlands, 2017 to 2023.
    Teker B, Schim van der Loeff MF, Deden L, …, Schouten J
    Euro Surveill · 2026 Jun SepsisNet
  26. Age-related differences in immune responses to inactivated influenza and adjuvanted recombinant herpes zoster vaccines.
    Kilic G, Taks EJ, Helder LS, …, Ten Oever J, Netea MG
    JCI Insight · 2026 Jul 22 SepsisNet
  27. Impact of appropriate antimicrobial therapy on patient outcomes and antimicrobial use: a sub analysis of the DIANA Study Dataset.
    Cidade JP, Póvoa P, Depuydt P, …, Schouten J
    Intensive Care Med · 2026 Jun SepsisNet
  28. Machine-learning algorithms identifies sTREM1 has a key biomarker for outcome prediction in critically ill.
    de Roquetaillade C, Blot PL, Uhel F, …, Van Der Poll T
    Crit Care · 2026 May 27 SepsisNet
  29. The Lancet Commission on Sepsis: transforming sepsis care and outcomes.
    Shankar-Hari M, Ming D, Mendelson M, …, van der Poll T
    Lancet · 2026 Oct 10 SepsisNet
  30. Strength of Omics in Uncovering Sepsis Mechanisms-A Perspective.
    Dorobantu S, Grigorescu A, Fratea A, …, Netea M
    Curr Health Sci J · 2025 Oct-Dec SepsisNet
  31. Challenges in early detection and prognostication of sepsis: new approaches from the emergency department and intensive care unit.
    Lafon T, Weingart M, Vaidie J, …, van der Poll T
    EClinicalMedicine · 2026 Apr SepsisNet
  32. Host response signatures across sepsis aetiologies in India: a single centre observational study.
    Biemond JJ, Earny VA, Virk H, …, Peters-Sengers H, Wiersinga WJ, van der Poll T
    Lancet Reg Health Southeast Asia · 2026 Apr SepsisNet
  33. Quantifying immune dysregulation in pneumonia and sepsis with a parsimonious machine-learning model: a multicohort analysis across care settings and reanalysis of a hydrocortisone randomised controlled trial.
    Michels EHA, Dequin PF, Butler JM, …, Bos LDJ, Cremer OL, Wiersinga WJ, Peters-Sengers H, van der Poll T
    Lancet Respir Med · 2026 Apr SepsisNet
  34. Editorial: The impact of proteomics on understanding inflammatory and infectious diseases.
    Leite GGF, Carregari VC, Peters-Sengers H et al.
    Front Immunol · 2026 SepsisNet
  35. Healthcare providers' experiences in caring for MDRO carriers with a focus on the moral dimensions of care: a systematic review.
    Damsté C, Stoorvogel H, Oerlemans A, …, Ten Oever J
    J Antimicrob Chemother · 2026 Mar 4 SepsisNet
  36. VExUS-ED: Early venous congestion is associated with clinical fluid overload in patients with sepsis.
    Ter Horst S, van Oosten J, Laros R, …, Bouma HR
    J Crit Care · 2026 Aug SepsisNet
  37. Perpetual observational study of the clinical and microbiological epidemiology of ventilator-associated pneumonia in Europe.
    Jackson H, Hernandez Padilla AC, Vintcent LEM, …, Cremer O
    Crit Care · 2026 Mar 12 SepsisNet
  38. Procalcitonin and interleukin-6 to diagnose infection in cardiac surgery patients with hyperinflammation: a two-centre, prospective cross-sectional study.
    Reniers T, Noordzij P, Harding E, …, Cremer O
    BJA Open · 2026 Mar SepsisNet
  39. Real-world longitudinal validation of high-income-country-derived sepsis endotypes in sub-Saharan Africa: a nested prospective multicenter study.
    Turgman O, Butler JM, Haguma P, …, van der Poll T, Wiersinga WJ
    Crit Care · 2026 Feb 25 SepsisNet
  40. Early risk assessment of severe outcomes in patients with suspected infection in the emergency department using clinical scores in a multicenter international validation.
    Hincapié-Osorno C, van der Aart TJ, van Wijk RJ, …, Ten Oever J, Bouma HR
    J Infect Public Health · 2026 Apr SepsisNet
  41. Nutritional practices and impact of feeding adequacy on clinical outcomes in Chinese respiratory intensive care units patients: a prospective observational study (ORIENT study).
    Huang X, Wang Y, Geng S, …, van Zanten A
    Front Nutr · 2025 SepsisNet
  42. Endothelial glycocalyx degradation and its association with clinical outcomes and host response aberrations in community-acquired pneumonia across different care settings.
    Wang H, Michels EHA, Cai M, …, Cremer OC, Peters-Sengers H, Wiersinga WJ, van der Poll T
    Crit Care · 2026 Jan 27 SepsisNet
  43. FLUid management and InDividualized resuscitation in Sepsis (FLUIDS)-A Study protocol for a single-centre, open-label, randomized clinical trial.
    Ter Horst S, Ter Avest E, van Everdink J, …, van Meurs M, Bouma HR
    PLoS One · 2025 SepsisNet
  44. Impact of meningoencephalitis and sepsis on delirium and subsequent neurological impairment in pediatric patients: a prospective proof-of-concept biomarker and EEG study.
    Klawitter F, Hackenberg J, Danckert L, …, Peters-Sengers H
    Sci Rep · 2025 Dec 8 SepsisNet
  45. Precision Immunotherapy to Improve Sepsis Outcomes: The ImmunoSep Randomized Clinical Trial.
    Giamarellos-Bourboulis EJ, Kotsaki A, Kotsamidi I, …, van der Poll T, Wiersinga WJ, Netea MG
    JAMA · 2026 Mar 3 SepsisNet
  46. Temporal robustness of biomarker-based classification algorithms for sepsis.
    Rademaker E, van Amstel RBE, El Bouhaddani S, …, van Vught L, van der Poll T, Bos LDJ, Cremer OL
    Intensive Care Med · 2026 Jan SepsisNet
  47. Thirty years of mHLA-DR research in septic shock: lessons and caveats for clinical translation.
    Bermejo-Martin JF, Cavaillon JM, Bouma H
    Intensive Care Med · 2026 Jan SepsisNet
  48. Cytomegalovirus reactivation and the host immune response in patients with sepsis.
    de Brabander J, Ong DSY, Cremer OL, …, Bos LDJ, Peters-Sengers H, van der Poll T
    J Infect · 2025 Dec SepsisNet
  49. A mixed methods approach (EXPANS) to assess current and future uses of antimicrobials: a case study of ceftaroline.
    Stoorvogel HH, Hulscher MEJL, Kolwijck E, …, Schouten JA, Ten Oever J
    Eur J Clin Microbiol Infect Dis · 2026 Mar SepsisNet
  50. Role of Myeloid Cell Glucose Transporter 1 in the Host Response During Pneumonia Caused by Streptococcus pneumoniae.
    Pereverzeva L, Léopold V, Saris A, …, Wiersinga WJ, van der Poll T
    Int J Mol Sci · 2025 Oct 28 SepsisNet
  51. Implementing a sepsis prediction score in out-of-hours primary care: Feasibility and acceptability study.
    Loots FJ, van Vught LA, van den Brande M, …, van Zanten ARH, Kaasjager K, Venekamp RP
    Eur J Gen Pract · 2025 Dec SepsisNet
  52. Dutch guideline for the prevention and control of multidrug-resistant organisms in the hospital setting, 2024 update.
    Sussenbach AE, Weterings V, Bathoorn E, …, Ten Oever J
    Antimicrob Resist Infect Control · 2025 Nov 7 SepsisNet
  53. The proteomic landscape of blood monocytes in community-acquired pneumonia.
    Chouchane O, Michels EHA, Leite GGF, …, Wiersinga WJ, van der Poll T
    Eur Respir J · 2025 Dec SepsisNet
  54. Risk conditions for invasive pneumococcal disease in adults: a systematic review and meta-analysis.
    Ditzel K, Giardina F, Ten Oever J et al.
    EClinicalMedicine · 2025 Nov SepsisNet
  55. Predicting 30-day mortality in emergency department patients with suspected infection: external validation of the RISE UP score in a single tertiary centre.
    van Baar de Knegt SME, Uffen JW, de Hond TAP, …, Stassen PM, Zelis N, Kaasjager KAH
    BMJ Open · 2025 Oct 23 SepsisNet
  56. Sepsis-associated acute kidney injury in mice and humans elicits heterogeneous renal microvascular microRNA responses.
    Luxen M, van der Aart TJ, Jongman RM, …, Bouma HR, van Meurs M
    Sci Rep · 2025 Oct 2 SepsisNet
  57. A consensus immune dysregulation framework for sepsis and critical illnesses.
    Moore AR, Zheng H, Ganesan A, …, van der Poll T, Bouma HR
    Nat Med · 2025 Dec SepsisNet
  58. A consensus blood transcriptomic framework for sepsis.
    Scicluna BP, Cano-Gamez K, Burnham KL, …, Cremer OL, van der Poll T
    Nat Med · 2025 Dec SepsisNet
  59. Effect of the gut microbiota-derived tryptophan metabolite indole-3-acetic acid in pneumonia.
    Kullberg RFJ, van Linge CCA, Haak BW, …, Cremer OL, van der Poll T, Wiersinga WJ
    Nat Commun · 2025 Sep 29 SepsisNet
  60. Diagnostic characteristics of the Rapid ESBL NP(®) test and ResistanceFinder 2SMART multiplex PCR for the detection of ESBL directly on urine samples.
    Bot MW, Flipse J, Bongers SLM, …, Ten Oever J
    Eur J Clin Microbiol Infect Dis · 2025 Dec SepsisNet
  61. The immunology of sepsis: translating new insights into clinical practice.
    Kox M, Bauer M, Bos LDJ, …, Bouma H, Netea MG, van der Poll T, van Vught LA
    Nat Rev Nephrol · 2026 Jan SepsisNet
  62. Patient-reported Perceptions, Experiences, and Preferences Around Intravenous and Oral Antibiotics for the Treatment of Staphylococcus aureus Bacteremia: A Descriptive Qualitative Study.
    Walls G, McGrath L, Herdman MT, …, Ten Oever J
    Clin Infect Dis · 2026 Apr 30 SepsisNet
  63. Longitudinal functional and neuropsychological 2-year follow-up after intensive care admission for multisystem inflammatory syndrome in children.
    Ketharanathan N, Buysse CMP, Seijbel TC, …, Bos L
    Eur J Pediatr · 2025 Sep 15 SepsisNet
  64. Long-term effects of influenza and Bacille Calmette-Guérin vaccination on systemic inflammation.
    Debisarun PA, Röring RJ, Bulut Ö, …, Ten Oever J, Netea MG
    Clin Transl Immunology · 2025 SepsisNet
  65. A Novel Approach to Early Personalized Hemodynamic Resuscitation: Non-Invasive Peripheral Photoplethysmography for Identifying Predominant Vasodilatory Shock in Sepsis.
    Ter Horst S, Schoonhoven AD, van Wijk RJ, …, Bouma HR
    Acta Anaesthesiol Scand · 2025 Oct SepsisNet
  66. Validation of plasma microRNAs as biomarkers in sepsis associated acute kidney injury upon first clinical presentation reveals limited diagnostic and prognostic performance.
    van der Aart TJ, Luxen M, Koeze J, …, van Meurs M, Bouma HR
    PLoS One · 2025 SepsisNet
  67. Uncovering molecular markers of the microvascular endothelial response in sepsis-associated acute kidney injury: a translational study in mice and humans.
    van der Aart TJ, Molema G, Jongman RM, …, Bouma HR, van Meurs M
    Intensive Care Med Exp · 2025 Sep 2 SepsisNet
  68. Seasonal Coronavirus-Induced Immunological Imprinting and Previous Herpesvirus Infections in Patients With Long COVID.
    Mak WA, Wapperom D, Redel AL, …, van der Poll T
    J Med Virol · 2025 Sep SepsisNet
  69. Establishing the pivotal role of infectious diseases and clinical microbiology professional societies: A global survey.
    Wertheim H, Pulcini C, Johnstone F, …, Schouten J
    J Glob Antimicrob Resist · 2025 Dec SepsisNet
  70. Transforming sepsis management: AI-driven innovations in early detection and tailored therapies.
    Papareddy P, Lobo TJ, Holub M, …, Bouma H
    Crit Care · 2025 Aug 19 SepsisNet
  71. A phase I trial evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenously administered low-anticoagulant heparin (M6229) in critically ill sepsis patients.
    van Mourik N, van Amstel RBE, Slim MA, …, van Vught LA, van der Poll T
    Intensive Care Med Exp · 2025 Aug 18 SepsisNet
  72. Development and validation of an interpretable machine learning model for retrospective identification of suspected infection for sepsis surveillance: a multicentre cohort study.
    Tuinte RAM, Smolenaers LPJ, Knoop BT, …, Bouma HR, Netea MG, Ten Oever J
    EClinicalMedicine · 2025 Sep SepsisNet
  73. How do experts classify sepsis cases for sepsis surveillance? Lessons learned from a Behavioural Artificial Intelligence Technology (BAIT) approach.
    Tuinte RAM, Heyning N, Ten Broeke A, …, Ten Oever J
    J Crit Care · 2026 Feb SepsisNet
  74. Butyrate-producing gut bacterium Faecalibacterium prausnitzii protects against bacterial pneumonia.
    Kullberg RFJ, van Linge CCA, de Vos AF, …, van der Poll T, Wiersinga WJ
    Eur Respir J · 2025 Nov SepsisNet
  75. Towards novel BIOmarkers to diagnose SEPsis (BIOSEP) in the emergency room: a protocol for a multicentre, prospective cohort study.
    Reijnders E, Turgman O, Joosten SCM, …, Peters-Sengers H, van der Poll T, Wiersinga WJ
    BMJ Open · 2025 Aug 1 SepsisNet
  76. Complement Activation is More Pronounced in the Kidneys of Critically Ill Patients With COVID-19 Than in Those With Bacterial Sepsis.
    Alkaff FF, Talen GG, van den Heuvel MC, …, van Meurs M
    Kidney Int Rep · 2025 Jul SepsisNet
  77. From losing control to regaining control: Patient experiences of care for Staphylococcus aureus bacteremia.
    Hendriks MMC, Tuinte RAM, Oerlemans AJM, …, Netea MG, Ten Oever J
    Patient Educ Couns · 2025 Oct SepsisNet
  78. Biological drivers of the host response in sepsis.
    Wiersinga WJ, van der Poll T
    Thorax · 2026 Mar 13 SepsisNet
  79. The Plasma Proteome in Community-acquired Pneumonia: Pathophysiology, Outcome, and 10-Year Risk.
    Michels EHA, Peters-Sengers H, de Brabander J, …, Cremer OL, Wiersinga WJ, van der Poll T
    Am J Respir Crit Care Med · 2025 Nov SepsisNet
  80. Differential platelet protein release profiles in community-acquired pneumonia and COVID-19.
    Chouchane O, Léopold V, Michels EHA, …, Wiersinga WJ, van der Poll T
    ERJ Open Res · 2025 May SepsisNet
  81. Diagnostic testing and antibiotic stewardship for pneumonia in children worldwide: current developments and next steps.
    van de Maat JS, Redfern A, Bacha T, …, Schouten J
    Curr Opin Pediatr · 2025 Oct 1 SepsisNet
  82. Pathogen-specific host response in critically ill patients with blood stream infections: a nested case-control study.
    Butler JM, Peters-Sengers H, Reijnders TDY, …, van Vught LA, Wiersinga WJ, Cremer OL, van der Poll T
    EBioMedicine · 2025 Jul SepsisNet
  83. Why Has Biomarker-Guided Fluid Resuscitation for Sepsis Not Been Implemented in Clinical Practice?
    Ter Horst S, Ter Maaten JC, van Meurs M, …, Bouma HR
    Crit Care Explor · 2025 Jun 1 SepsisNet
  84. Moral tensions when providing care to MDRO carriers: A qualitative study among health care providers in Dutch hospitals and nursing homes.
    Damsté C, Oerlemans A, Knippenberg M, …, Ten Oever J
    Am J Infect Control · 2025 Aug SepsisNet
  85. Sepsis in patients who are immunocompromised: diagnostic challenges and future therapies.
    Deinhardt-Emmer S, Chousterman BG, Schefold JC, …, Kox M, Wiersinga WJ, van der Poll T, Bouma HR
    Lancet Respir Med · 2025 Jul SepsisNet
  86. Plasma H3.1 nucleosomes as biomarkers of infection, inflammation and organ failure.
    Filippini DFL, Jiang M, Kramer L, …, van der Poll T, Cremer O, Bos LDJ
    Crit Care · 2025 May 19 SepsisNet
  87. Pulse oximetry beyond oxygen saturation: Early waveform characteristics in sepsis patients with adverse outcomes - A proof-of-concept study.
    Ter Horst S, van Wijk RJ, Schoonhoven AD, …, Bouma HR
    J Crit Care · 2025 Oct SepsisNet
  88. Establishing core competencies for antimicrobial stewardship teams: a consensus development using the modified Delphi technique-an European Society of Clinical Microbiology and Infectious Diseases Study Group for Antimicrobial Stewardship position paper.
    Alves J, Schouten J, Thursky K et al.
    Clin Microbiol Infect · 2025 Aug SepsisNet
  89. Role of Liver Kinase 1B in Platelet Activation and Host Defense During Klebsiella pneumoniae-Induced Pneumosepsis.
    Chouchane O, Léopold V, van Linge CCA, …, van der Poll T
    Int J Mol Sci · 2025 Apr 14 SepsisNet
  90. Creating a prediction model for invasive candidiasis in the intensive care unit using a case control design: a European multicentre approach.
    Benders PMB, Schouten J, Vena A et al.
    BMC Infect Dis · 2025 May 4 SepsisNet
  91. Feasibility of whey protein powder supplementation in patients who are neurocritically ill: A post hoc analysis of a pilot randomized controlled trial.
    Tian F, van Zanten A, Liu G et al.
    Nutr Clin Pract · 2026 Feb SepsisNet
  92. Identification and validation of robust hospital-acquired pneumonia subphenotypes associated with all-cause mortality: a multi-cohort derivation and validation.
    Martin FP, Poulain C, Mulier JH, …, Cremer O
    Intensive Care Med · 2025 Apr SepsisNet
  93. Systemic inflammation impairs myelopoiesis and interferon type I responses in humans.
    Keramati F, Leijte GP, Bruse N, …, Netea MG, Kox M
    Nat Immunol · 2025 May SepsisNet
  94. Two Case Reports of Interferon-γ Therapy in Patients with Aspergillus Tracheobronchitis Who Developed an Immunocompromised State After Severe Abdominal Sepsis.
    Tramper T, Schouten J, Kox M et al.
    Am J Case Rep · 2025 Apr 2 SepsisNet
  95. Haemoadsorption to remove inflammatory mediators in sepsis: past, present, and future.
    Waalders NJB, Kox M, Pickkers P
    Intensive Care Med Exp · 2025 Mar 21 SepsisNet
  96. Host Response Protein Biomarkers Indicative of Persistent Acute Kidney Injury in Critically Ill COVID-19 Patients.
    Steenvoorden TS, de Kruijf KC, Appelman B, …, Bos LDJ, van Vught LA, Wiersinga WJ, van der Poll T, Peters-Sengers H
    Crit Care Explor · 2025 Mar 1 SepsisNet
  97. Comparison Between Signal Transduction Pathway Activity in Blood Cells of Sepsis Patients and Laboratory Models.
    Bouwman W, Raymakers R, van der Poll T et al.
    Cells · 2025 Feb 19 SepsisNet
  98. [(18)F]FDG PET/CT identifies infectious and inflammatory foci in persistent critical illness.
    van Leer B, Haitsma Mulier JLG, van Stee CP, …, van Meurs M
    Ann Intensive Care · 2025 Feb 20 SepsisNet
  99. A Longitudinal Description of the Health-Related Quality of Life Among Individuals at High Risk After SARS-CoV-2 Infection: A Dutch Multicenter Observational Cohort Study.
    Vergouwe M, Birnie E, van Veelen S, …, Peters-Sengers H, Wiersinga WJ
    Open Forum Infect Dis · 2025 Feb SepsisNet
  100. Clinical subtypes in critically ill patients with sepsis: validation and parsimonious classifier model development.
    van Amstel RBE, Rademaker E, Kennedy JN, …, Bos LDJ, Peters-Sengers H, Kox M, van der Poll T, Cremer OL, van Vught LA
    Crit Care · 2025 Feb 4 SepsisNet
  101. Bryostatin-1 enhances the proliferation and functionality of exhausted CD8+ T cells by upregulating MAP Kinase 11.
    Li L, Zhao M, van Meurs M et al.
    Front Immunol · 2024 SepsisNet
  102. The blood transcriptional response in patients developing intensive care unit-acquired pneumonia.
    de Brabander J, Michels EHA, Butler JM, …, Peters-Sengers H, van der Poll T
    Eur Respir J · 2025 Apr SepsisNet
  103. Extracellular matrix turnover in severe COVID-19 is reduced by corticosteroids.
    Pillay J, Flikweert AW, van Meurs M et al.
    Respir Res · 2025 Jan 22 SepsisNet
  104. Aiming for precision: personalized medicine through sepsis subtyping.
    Kolodyazhna A, Wiersinga WJ, van der Poll T
    Burns Trauma · 2025 SepsisNet
  105. Temporal Transitions of the Hyperinflammatory and Hypoinflammatory Phenotypes in Critical Illness.
    van Amstel RBE, Bartek B, Vlaar APJ, …, van Vught LA, Cremer OL, Van der Poll T, Bos LDJ
    Am J Respir Crit Care Med · 2025 Mar SepsisNet
  106. Longitudinal assessment of immunoglobulin response and disease progression in critically ill patients with community acquired pneumonia.
    Rademaker E, Vernooij LM, van der Poll T, …, Cremer OL
    Crit Care · 2024 Dec 5 SepsisNet
  107. Mathematical model of the inflammatory response to acute and prolonged lipopolysaccharide exposure in humans.
    Relouw FJA, Kox M, Taal HR et al.
    NPJ Syst Biol Appl · 2024 Dec 5 SepsisNet
  108. International multi-cohort analysis identifies novel framework for quantifying immune dysregulation in critical illness: results of the SUBSPACE consortium.
    Moore AR, Zheng H, Ganesan A, …, van der Poll T
    bioRxiv · 2024 Nov 15 SepsisNet
  109. Clinical Subtype Trajectories in Sepsis Patients Admitted to the ICU: A Secondary Analysis of an Observational Study.
    Slim MA, van Amstel RBE, Müller MCA, …, Cremer OL, van der Poll T, Wiersinga WJ, van Vught LA
    Crit Care Explor · 2024 Nov SepsisNet
  110. The effect of BCG vaccination in the elderly on infectious and non-infectious immune-mediated diseases.
    Dulfer EA, Föhse K, Taks EJM, …, Ten Oever J, Netea MG
    J Infect · 2024 Dec SepsisNet
  111. Proteomic profiling of neutrophils and plasma in community-acquired pneumonia reveals crucial proteins in diverse biological pathways linked to clinical outcome.
    Michels EHA, Chouchane O, de Brabander J, …, Wiersinga WJ, van der Poll T
    Front Immunol · 2024 SepsisNet
  112. Rapid and Robust Identification of Sepsis Using SeptiCyte RAPID in a Heterogeneous Patient Population.
    Balk R, Esper AM, Martin GS, …, van der Poll T
    J Clin Med · 2024 Oct 10 SepsisNet
  113. Postoperative Innate Immune Dysregulation, Proteomic, and Monocyte Epigenomic Changes After Colorectal Surgery: A Substudy of a Randomized Controlled Trial.
    Albers-Warlé KI, Helder LS, Groh LA, …, Kox M, Netea MG
    Anesth Analg · 2025 Jan 1 SepsisNet
  114. Quantitative characterization of immune cells by measuring cellular signal transduction pathway activity.
    Bouwman W, Verhaegh W, van Doorn A, …, van der Poll T
    Sci Rep · 2024 Oct 18 SepsisNet
  115. Unraveling Sepsis Epidemiology in a Low- and Middle-Income Intensive Care Setting Reveals the Alarming Burden of Tropical Infections and Antimicrobial Resistance: A Prospective Observational Study (MARS-India).
    Virk HS, Biemond JJ, Earny VA, …, van der Poll T, Wiersinga WJ
    Clin Infect Dis · 2025 Feb 5 SepsisNet
  116. Plasma Inflammatory Proteome Profile in a Cohort of Patients with Recurrent Vulvovaginal Candidiasis in Kenya.
    Rosati D, Ricaño Ponce I, Omosa-Manyonyi GS, …, Netea MG, Ten Oever J
    J Fungi (Basel) · 2024 Sep 6 SepsisNet
  117. Effect of mesenchymal stem cells on the host response in severe community-acquired pneumonia.
    Reijnders TDY, Laterre PF, François B, …, van der Poll T
    Thorax · 2024 Oct 16 SepsisNet
  118. Topical adjunctive treatment with flagellin augments pulmonary neutrophil responses and reduces bacterial dissemination in multidrug-resistant K. pneumoniae infection.
    van Linge CCA, Kullberg RFJ, Chouchane O, …, van der Poll T
    Front Immunol · 2024 SepsisNet
  119. Single-cell transcriptomics reveals subset-specific metabolic profiles underpinning the bronchial epithelial response to flagellin.
    Ramirez-Moral I, Schuurman AR, van Linge CCA, …, van der Poll T
    iScience · 2024 Sep 20 SepsisNet
  120. Heterogeneous Patterns of Endothelial NF-κB p65 and MAPK c-Jun Activation, Adhesion Molecule Expression, and Leukocyte Recruitment in Lung Microvasculature of Mice with Sepsis.
    Wang Z, Dayang EZ, Zwiers PJ, …, van Meurs M
    Biomedicines · 2024 Jul 26 SepsisNet
  121. Nurses' contribution to antimicrobial stewardship: business as usual?
    Bos M, de Bot C, Vermeulen H, …, Schouten J
    Antimicrob Resist Infect Control · 2024 Aug 29 SepsisNet
  122. European society of clinical microbiology and infectious diseases guidelines for antimicrobial stewardship in emergency departments (endorsed by European association of hospital pharmacists).
    Schoffelen T, Papan C, Carrara E, …, Schouten J
    Clin Microbiol Infect · 2024 Nov SepsisNet
  123. Pulmonary herpes simplex virus and cytomegalovirus in patients with acute respiratory distress syndrome related to COVID-19.
    Boers LS, van Someren Gréve F, van Hattem JM, …, van der Poll T, Bos LDJ
    Intensive Care Med · 2024 Aug SepsisNet
  124. Recruitment of neutrophils in glomeruli in early mouse sepsis is associated with E-selectin expression and activation of endothelial nuclear factor kappa-light-chain-enhancer of activated B cells and mitogen-activated protein kinase pathways.
    Wang Z, Dayang EZ, Zwiers PJ, …, van Meurs M
    J Leukoc Biol · 2024 Nov 27 SepsisNet
  125. Association between butyrate-producing gut bacteria and the risk of infectious disease hospitalisation: results from two observational, population-based microbiome studies.
    Kullberg RFJ, Wikki I, Haak BW, …, Peters-Sengers H, Wiersinga WJ
    Lancet Microbe · 2024 Sep SepsisNet
  126. Follow-up of patients with urinary tract infections discharged from the emergency department: a mixed methods study.
    Tuinte RAM, van Zanten MD, Takamura T, …, Schouten JA, Ten Oever J
    J Antimicrob Chemother · 2024 Jul 1 SepsisNet
  127. Towards personalized medicine: a scoping review of immunotherapy in sepsis.
    Slim MA, van Mourik N, Bakkerus L, …, Netea MG, van der Poll T, Wiersinga WJ, van Vught LA
    Crit Care · 2024 May 28 SepsisNet
  128. Examining pancreatic stone protein response in ICU-acquired bloodstream infections: a matched event analysis.
    Verlaan D, Derde LPG, van der Poll T, …, Cremer OL
    Intensive Care Med Exp · 2024 May 28 SepsisNet
  129. From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations for Developing Precision Medicine in the ICU.
    Gordon AC, Alipanah-Lechner N, Bos LD, …, van der Poll T
    Am J Respir Crit Care Med · 2024 Jul 15 SepsisNet
  130. Neo-epitope detection identifies extracellular matrix turnover in systemic inflammation and sepsis: an exploratory study.
    Fan Y, Moser J, van Meurs M, …, Kox M
    Crit Care · 2024 Apr 12 SepsisNet
  131. Validation of SeptiCyte RAPID to Discriminate Sepsis from Non-Infectious Systemic Inflammation.
    Balk R, Esper AM, Martin GS, …, van der Poll T
    J Clin Med · 2024 Feb 20 SepsisNet
  132. Sepsis induces heterogeneous transcription of coagulation- and inflammation-associated genes in renal microvasculature.
    Luxen M, Zwiers PJ, Jongman RM, …, van Meurs M
    Thromb Res · 2024 May SepsisNet
  133. Low-Risk Staphylococcus aureus Bacteremia Patients Do Not Require Routine Diagnostic Imaging: A Multicenter, Retrospective, Cohort Study.
    Hendriks MMC, Schweren KSA, Kleij A, …, Netea MG, Ten Oever J
    Clin Infect Dis · 2024 Jul 19 SepsisNet
  134. Gut barrier dysfunction and the risk of ICU-acquired bacteremia- a case-control study.
    Varkila MRJ, Verboom DM, Derde LPG, …, van der Poll T, Cremer OL
    Ann Intensive Care · 2024 Mar 27 SepsisNet
  135. When to Stop Antibiotics in the Critically Ill?
    Nielsen ND, Dean JT 3rd, Shald EA, …, Schouten J
    Antibiotics (Basel) · 2024 Mar 18 SepsisNet
  136. Monocyte state 1 (MS1) cells in critically ill patients with sepsis or non-infectious conditions: association with disease course and host response.
    Leite GGF, de Brabander J, Michels EHA, …, Cremer OL, Peters-Sengers H, van der Poll T
    Crit Care · 2024 Mar 19 SepsisNet
  137. Lymphopenia is associated with broad host response aberrations in community-acquired pneumonia.
    Doeleman SE, Reijnders TDY, Joosten SCM, …, Wiersinga WJ, van der Poll T
    J Infect · 2024 Apr SepsisNet
  138. Reframing sepsis immunobiology for translation: towards informative subtyping and targeted immunomodulatory therapies.
    Shankar-Hari M, Calandra T, Soares MP, …, Wiersinga WJ, Bos LDJ, van der Poll T
    Lancet Respir Med · 2024 Apr SepsisNet
  139. Myeloid-Derived Suppressor-like Cells as a Prognostic Marker in Critically Ill Patients: Insights from Experimental Endotoxemia and Intensive Care Patients.
    Schrijver IT, Herderschee J, Théroude C, …, Kox M
    Cells · 2024 Feb 8 SepsisNet
  140. The shifting lipidomic landscape of blood monocytes and neutrophils during pneumonia.
    Schuurman AR, Chouchane O, Butler JM, …, Peters-Sengers H, Wiersinga WJ, van der Poll T
    JCI Insight · 2024 Feb 22 SepsisNet
  141. Phenotype-specific therapeutic efficacy of ilofotase alfa in patients with sepsis-associated acute kidney injury.
    Bruse N, Pardali K, Kraan M, …, Kox M
    Crit Care · 2024 Feb 19 SepsisNet
  142. Systemic inflammation relates to neuroaxonal damage associated with long-term cognitive dysfunction in COVID-19 patients.
    Duindam HB, Mengel D, Kox M et al.
    Brain Behav Immun · 2024 Mar SepsisNet
  143. The Plasma Lipidomic Landscape in Patients with Sepsis due to Community-acquired Pneumonia.
    Chouchane O, Schuurman AR, Reijnders TDY, …, Peters-Sengers H, Cremer OL, van der Poll T
    Am J Respir Crit Care Med · 2024 Apr 15 SepsisNet
  144. The impact of high versus standard enteral protein provision on functional recovery following intensive care admission: Protocol for a pre-planned secondary Bayesian analysis of the PRECISe trial.
    Heuts S, de Heer P, Gabrio A, …, van Zanten A
    Clin Nutr ESPEN · 2024 Feb SepsisNet
  145. Immunostimulatory Effect of Flagellin on MDR-Klebsiella-Infected Human Airway Epithelial Cells.
    van Linge CCA, Hulme KD, Peters-Sengers H, …, van der Poll T
    Int J Mol Sci · 2023 Dec 25 SepsisNet
  146. NSAID prescribing and adverse outcomes in common infections: a population-based cohort study.
    Stuart B, Venekamp R, Hounkpatin H et al.
    BMJ Open · 2024 Jan 3 SepsisNet
  147. The pathophysiology of sepsis and precision-medicine-based immunotherapy.
    Giamarellos-Bourboulis EJ, Aschenbrenner AC, Bauer M, …, van der Poll T, Wiersinga WJ, Netea MG
    Nat Immunol · 2024 Jan SepsisNet
  148. Multiplexed multicolor antiviral assay amenable for high-throughput research.
    Li LH, Chiu W, Huang YA, …, Ter Horst S
    Nat Commun · 2024 Jan 2 SepsisNet
  149. Profiling the dysregulated immune response in sepsis: overcoming challenges to achieve the goal of precision medicine.
    Cajander S, Kox M, Scicluna BP et al.
    Lancet Respir Med · 2024 Apr SepsisNet
  150. High-dimensional phenotyping of the peripheral immune response in community-acquired pneumonia.
    Reijnders TDY, Schuurman AR, Verhoeff J, …, Wiersinga WJ, van der Poll T
    Front Immunol · 2023 SepsisNet
  151. Hydrocortisone-associated death and hospital length of stay in patients with sepsis: A retrospective cohort of large-scale clinical care data.
    Li M, Noordam R, Winter EM, …, van Meurs M, Bouma HR
    Biomed Pharmacother · 2024 Jan SepsisNet
  152. Early Oral Antibiotic Switch in Staphylococcus aureus Bacteraemia: The Staphylococcus aureus Network Adaptive Platform (SNAP) Trial Early Oral Switch Protocol.
    de Kretser D, Mora J, Bloomfield M, …, Ten Oever J
    Clin Infect Dis · 2024 Oct 15 SepsisNet
  153. Non-conventional immunomodulation in the management of sepsis.
    Slim MA, Turgman O, van Vught LA, …, van der Poll T, Wiersinga WJ
    Eur J Intern Med · 2024 Mar SepsisNet
  154. The safety and efficacy of stem cells for the treatment of severe community-acquired bacterial pneumonia: A randomized clinical trial.
    Laterre PF, Sánchez García M, van der Poll T et al.
    J Crit Care · 2024 Feb SepsisNet
  155. Myeloid miR-155 plays a limited role in antibacterial defense during Klebsiella-derived pneumosepsis and is dispensable for lipopolysaccharide- or Klebsiella-induced inflammation in mice.
    Qin W, Saris A, van 't Veer C, …, van der Poll T
    Pathog Dis · 2023 Jan 17 SepsisNet
  156. Uncovering heterogeneity in sepsis: a comparative analysis of subphenotypes.
    van Amstel RBE, Kennedy JN, Scicluna BP, …, Bos LDJ, Peters-Sengers H, Cremer OL, van der Poll T, van Vught LA
    Intensive Care Med · 2023 Nov SepsisNet
  157. Sex differences in clinical presentation and mortality in emergency department patients with sepsis.
    Wanrooij VHM, Cobussen M, Stoffers J, …, Zelis N, Stassen PM
    Ann Med · 2023 SepsisNet
  158. Reduced Tie2 in Microvascular Endothelial Cells Is Associated with Organ-Specific Adhesion Molecule Expression in Murine Health and Endotoxemia.
    Zwiers PJ, Lucas JPFE, Jongman RM, …, van Meurs M
    Cells · 2023 Jul 14 SepsisNet
  159. Inflammatory and glycolytic programs underpin a primed blood neutrophil state in patients with pneumonia.
    Schuurman AR, Butler JM, Michels EHA, …, Wiersinga WJ, van der Poll T
    iScience · 2023 Jul 21 SepsisNet
  160. Routine vaccination for influenza and pneumococcal disease and its effect on COVID-19 in a population of Dutch older adults.
    Taks EJM, Föhse K, J C F M Moorlag S, …, Netea MG, Ten Oever J
    Vaccine X · 2023 Aug SepsisNet
  161. Plasma protein biomarkers reflective of the host response in patients developing Intensive Care Unit-acquired pneumonia.
    van Engelen TSR, Reijnders TDY, Paling FP, …, Peters-Sengers H, van der Poll T
    Crit Care · 2023 Jul 6 SepsisNet
  162. Inflammatory biomarkers to predict the prognosis of acute bacterial and viral infections.
    de Nooijer AH, Pickkers P, Netea MG, …, Kox M
    J Crit Care · 2023 Dec SepsisNet
  163. Resolving sepsis-induced immunoparalysis via trained immunity by targeting interleukin-4 to myeloid cells.
    Schrijver DP, Röring RJ, Deckers J, …, Kox M, Netea MG
    Nat Biomed Eng · 2023 Sep SepsisNet
  164. Nuclear segmentation facilitates neutrophil migration.
    Shen C, Mulder E, Buitenwerf W, …, Kox M
    J Cell Sci · 2023 Jun 1 SepsisNet
  165. Characteristics of mpox positive, versus mpox negative, and mpox unsuspected clients from the Centre of Sexual Health, Public Health Service of Amsterdam, 20 May to 15 September 2022.
    Siegenbeek van Heukelom ML, Jongen VW, Schouten J et al.
    J Eur Acad Dermatol Venereol · 2023 Sep SepsisNet
  166. Incidence of idiopathic nephrotic syndrome during the Covid-19 pandemic in the Paris area (France) and in the Netherlands.
    Veltkamp F, Thenot V, Mussies C, …, Peters-Sengers H
    Pediatr Nephrol · 2023 Nov SepsisNet
  167. The battle against fungi: lessons in antifungal stewardship from COVID 19 times.
    Kanj SS, Haddad SF, Meis JF, …, Schouten J
    Int J Antimicrob Agents · 2023 Jul SepsisNet
  168. Persistent alveolar inflammatory response in critically ill patients with COVID-19 is associated with mortality.
    de Brabander J, Boers LS, Kullberg RFJ, …, van der Poll T, Bos LDJ
    Thorax · 2023 Sep SepsisNet
  169. ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia.
    Martin-Loeches I, Torres A, Nagavci B, …, Bos L
    Eur Respir J · 2023 Apr SepsisNet
  170. Evidence-based rationale for low dose nivolumab in critically ill patients with sepsis-induced immunosuppression.
    van den Haak DAC, Otten LS, Koenen HJPM, …, Kox M
    Clin Transl Sci · 2023 Jun SepsisNet
  171. CytoSorb hemoperfusion markedly attenuates circulating cytokine concentrations during systemic inflammation in humans in vivo.
    Jansen A, Waalders NJB, van Lier DPT, …, Kox M
    Crit Care · 2023 Mar 21 SepsisNet
  172. Embracing complexity in sepsis.
    Schuurman AR, Sloot PMA, Wiersinga WJ, …, van der Poll T
    Crit Care · 2023 Mar 11 SepsisNet
  173. The impact of circadian rhythm on Bacillus Calmette-Guérin vaccination effects on SARS-CoV-2 infections.
    Föhse K, Taks EJM, Moorlag SJCFM, …, Ten Oever J, Netea MG
    Front Immunol · 2023 SepsisNet
  174. THE EUROPEAN SHOCK SOCIETY MEETS THE IMMUNOSEP CONSORTIUM FOR PERSONALIZED SEPSIS TREATMENT.
    Giamarellos-Bourboulis EJ, Dimopoulos G, Flohé S, …, van der Poll T, Netea MG
    Shock · 2023 Mar 1 SepsisNet
  175. Complement activation in severely ill patients with sepsis: no relationship with inflammation and disease severity.
    de Nooijer AH, Kotsaki A, Kranidioti E, …, Kox M, Netea MG
    Crit Care · 2023 Feb 16 SepsisNet
  176. Artificial Intelligence for Early Sepsis Detection: A Word of Caution.
    Schinkel M, van der Poll T, Wiersinga WJ
    Am J Respir Crit Care Med · 2023 Apr 1 SepsisNet
  177. Low SARS-CoV-2 Cq values in healthcare workers with symptomatic COVID-19 infections, regardless of symptom severity, The Netherlands, January to August 2022.
    van Rossum C, Meijer C, van Weerdenburg IJ, …, Ten Oever J
    Euro Surveill · 2023 Jan SepsisNet
  178. ImmunoSep (Personalised Immunotherapy in Sepsis) international double-blind, double-dummy, placebo-controlled randomised clinical trial: study protocol.
    Kotsaki A, Pickkers P, Bauer M, …, Wiersinga WJ, van der Poll T, van Vught L, Netea MG
    BMJ Open · 2022 Dec 20 SepsisNet
  179. Role of Hypoxia-inducible factor 1α in host defense during pneumococcal pneumonia.
    Pereverzeva L, Otto NA, Peters-Sengers H, …, van der Poll T
    Pathog Dis · 2023 Jan 17 SepsisNet
  180. Association between age and the host response in critically ill patients with sepsis.
    Michels EHA, Butler JM, Reijnders TDY, …, Cremer OL, Peters-Sengers H, van Vught LA, van der Poll T
    Crit Care · 2022 Dec 13 SepsisNet
  181. Immunopathophysiology of human sepsis.
    Wiersinga WJ, van der Poll T
    EBioMedicine · 2022 Dec SepsisNet
  182. Glucose metabolism is upregulated in the mononuclear cell proteome during sepsis and supports endotoxin-tolerant cell function.
    Ferreira BL, Sousa MB, Leite GGF, …, van der Poll T
    Front Immunol · 2022 SepsisNet
  183. Targeted proteomics identifies circulating biomarkers associated with active COVID-19 and post-COVID-19.
    Zoodsma M, de Nooijer AH, Grondman I, …, Kox M, Netea MG
    Front Immunol · 2022 SepsisNet
  184. Redefining Staphylococcus aureus bacteremia: A structured approach guiding diagnostic and therapeutic management.
    Kouijzer IJE, Fowler VG Jr, Ten Oever J
    J Infect · 2023 Jan SepsisNet
  185. An immune dysfunction score for stratification of patients with acute infection based on whole-blood gene expression.
    Cano-Gamez K, Burnham KL, Goh C, …, Peters-Sengers H, van der Poll T
    Sci Transl Med · 2022 Nov 2 SepsisNet
  186. Predictors of Nonseroconversion to SARS-CoV-2 Vaccination in Kidney Transplant Recipients.
    Frölke SC, Bouwmans P, Messchendorp AL, …, Peters-Sengers H
    Transplant Direct · 2022 Nov SepsisNet
  187. Activation of cytokine responses by Candida africana.
    Rosati D, Bruno M, van de Veerdonk F, …, Ten Oever J, Netea MG
    Med Mycol · 2022 Oct 12 SepsisNet
  188. Microglial response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice after systemic stimulation with Escherichia coli.
    Hoogland ICM, Yik J, Westhoff D, …, van der Poll T
    Neurosci Lett · 2022 Nov 1 SepsisNet
  189. The End of "One Size Fits All" Sepsis Therapies: Toward an Individualized Approach.
    Vincent JL, van der Poll T, Marshall JC
    Biomedicines · 2022 Sep 12 SepsisNet
  190. Myeloid liver kinase B1 contributes to lung inflammation induced by lipoteichoic acid but not by viable Streptococcus pneumoniae.
    Pereverzeva L, Otto NA, Roelofs JJTH, …, van der Poll T
    Respir Res · 2022 Sep 12 SepsisNet
  191. The Azithromycin Pro-Drug CSY5669 Boosts Bacterial Killing While Attenuating Lung Inflammation Associated with Pneumonia Caused by Methicillin-Resistant Staphylococcus aureus.
    Saris A, Qin W, van Linge CCA, …, van der Poll T
    Antimicrob Agents Chemother · 2022 Sep 20 SepsisNet
  192. Intracellular pyruvate levels positively correlate with cytokine production capacity in tolerant monocytes from patients with pneumonia.
    Otto NA, Butler JM, Schuurman AR, …, Wiersinga WJ, van der Poll T
    Biochim Biophys Acta Mol Basis Dis · 2022 Nov 1 SepsisNet
  193. Clinical sepsis phenotypes in critically ill COVID-19 patients.
    Bruse N, Kooistra EJ, Jansen A, …, van Vught LA, Kox M
    Crit Care · 2022 Aug 9 SepsisNet
  194. Ex vivo and in vitro Monocyte Responses Do Not Reflect in vivo Immune Responses and Tolerance.
    Jansen A, Bruse N, Waalders N, …, Kox M
    J Innate Immun · 2023 SepsisNet
  195. Rectal microbiota are coupled with altered cytokine production capacity following community-acquired pneumonia hospitalization.
    Kullberg RFJ, Brands X, Klarenbeek AM, …, van der Poll T, Wiersinga WJ
    iScience · 2022 Aug 19 SepsisNet
  196. Patients with hypothermic sepsis have a unique gene expression profile compared to patients with fever and sepsis.
    Harmon MBA, Scicluna BP, Wiewel MA, …, Cremer OL, van der Poll T
    J Cell Mol Med · 2022 Apr SepsisNet
  197. The Long Non-Coding Antisense RNA JHDM1D-AS1 Regulates Inflammatory Responses in Human Monocytes.
    Malmström E, Khan HN, Veer CV', …, van der Poll T
    Front Cell Infect Microbiol · 2022 SepsisNet
  198. Immune suppression is associated with enhanced systemic inflammatory, endothelial and procoagulant responses in critically ill patients.
    Brands X, Uhel F, van Vught LA, …, van der Poll T
    PLoS One · 2022 SepsisNet
  199. Current clinical practice in antibiotic treatment of Staphylococcus aureus bacteraemia: results from a survey in five European countries.
    Buis DTP, Prins JM, Betica-Radic L, …, Schouten J, Ten Oever J
    J Antimicrob Chemother · 2022 Sep 30 SepsisNet
  200. Mediators of Obesity Do Not Influence SARS-CoV-2 Infection or Activation of Primary Human Lung Microvascular Endothelial Cells In Vitro.
    Ter Ellen BM, Niewold J, Flikweert A, …, van Meurs M
    Front Immunol · 2022 SepsisNet

View the full list in PubMed →

Source: PubMed, updated automatically.

Research agenda

Where is more research needed?

The Netherlands has strong research groups and cohorts, but little dedicated funding for sepsis research. SepsisNet is working on a national research agenda and advocates a dedicated funding call. Priorities emerging in the network:

Recognition outside hospital

How can GPs, out-of-hours services and ambulance staff recognise sepsis earlier and hand over urgency well?

Subtypes and targeted therapy

Biological subtypes, biomarkers and drugs that prevent organ failure, from lab to trial.

Recovery and aftercare

Who has lasting problems, why, and which aftercare works? Including patients who were not in intensive care.

Measuring and learning

A pathway-based core registry linking existing sources (NICE, DICA, PREZIES) to monitor and improve care.

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