My research focuses on two closely related themes: sepsis and clinical nutrition in critically ill patients. In sepsis, I study the early treatment of circulatory failure, with particular attention to vasopressors, response profiles, kidney function and personalised haemodynamic support. In nutrition, I study how energy, protein and micronutrients can best be matched to the phase of illness, metabolic response, body composition and recovery. I combine randomised trials, multicentre cohorts, biomarkers, imaging and advanced analytical methods. The ultimate aim is to individualise treatment strategies, reduce complications and sustainably improve functional recovery, quality of life and survival of patients during and after intensive care admission.