My research comprises translational studies of the immune response in intensive care patients, with a strong focus on sepsis. I make extensive use of the experimental endotoxaemia model (LPS administration in healthy volunteers) to unravel immunological mechanisms and test potential new treatments. My research spans the full spectrum from molecule to population: from molecular research and animal studies to studies in healthy volunteers, clinical studies in patients and large cohort studies. I am an editor of Intensive Care Medicine Experimental, editor of the NVIC journal 'de Intensivist', and founder and board member of the European Group on the Immunology of Sepsis.
