Infection of the abdominal aortic endograft and synthetic shunt are life-threatening complications. Despite the development of modern methods of surgical treatment and antimicrobial therapy, the problem of infectious complications after aortic reconstructions using synthetic prostheses remains relevant. The search for optimal surgical approaches continues, including the use of biological materials such as homographs to replace infected structures. The article presents a clinical case of...

Continuous renal replacement therapy (CRRT) extracorporeal drug removal, sepsis-related pathophysiological alterations, and reduced pathogen susceptibility to antimicrobials can lead to treatment failure in septic patients undergoing CRRT, highlighting the urgent need for precision dosing. This study aimed to develop a physiologically based pharmacokinetic (PBPK) modeling framework to characterize antimicrobial pharmacokinetics and support dosing optimization in septic patients undergoing CRRT....

Early risk stratification in pediatric sepsis remains difficult because conventional inflammatory markers do not fully reflect endothelial injury or microcirculatory dysfunction. This single-center retrospective observational study evaluated whether heparin-binding protein provides prognostic information for organ dysfunction and disease severity in children with sepsis admitted to the pediatric intensive care unit. A total of 150 children with sepsis admitted to the People's Hospital of Guangxi...

CONCLUSION: The proposed BioBERT-BPNN multimodal model effectively integrates textual and numerical information and improves the performance of early SA-AKI recognition. Leveraging dual-center multi-source heterogeneous clinical data enhances its applicability in real-world clinical settings. This study could provide valuable reference for timely intervention, optimized decision-making, and improved outcomes in sepsis patients at risk of AKI, holding important clinical research value.