CONCLUSIONS: Peripheral immune states differ across the sepsis-to-AD spectrum and are captured by a MAFG-centered signature. Independent of any trajectory assumption, loss-of-function and adoptive-transfer experiments identify MAFG as a causal, redox-sensitive node constraining peripheral Aβ clearance and a candidate biomarker and therapeutic target in sepsis survivors.

CONCLUSIONS: Both SII and NLR are significant predictors of neonatal sepsis in LBW infants. SII demonstrates superior predictive performance and higher specificity compared with NLR.

CONCLUSION: AI-driven ECG analysis via a smartphone app provided a rapid, accessible, and accurate screening tool for LV dysfunction in sepsis and outperformed NT-proBNP. Its high NPV suggests potential utility for early risk stratification and for informing cautious hemodynamic management, although prospective studies are needed to define its role in sepsis treatment protocols.

CONCLUSION: Esmolol protects against SAMI by dual inhibition of the APAF1 mitochondrial apoptotic and JAK2/STAT3 inflammatory pathways, with APAF1 likely serving as a key downstream target of esmolol.