My research focuses on the pathogenesis and treatment of severe infections, with sepsis as the central theme. I study how immune dysregulation and pathogen-host interactions contribute to organ failure, with the aim of developing new biomarkers and targeted treatments. I combine clinical cohorts with translational research and multi-omics. Key research lines are the gut microbiome in severe infection, pneumonia and tropical infections, in particular melioidosis. I am also active in national and international sepsis networks (chair-elect of the International Sepsis Forum) and in guideline development (SWAB, Surviving Sepsis Campaign).
