CONCLUSIONS: In this single-center retrospective descriptive study, PDNA was most commonly administered at CNI initiation, and administration was followed by an early increase in median MAP. However, the noncomparative design and concurrent resuscitative interventions preclude attribution of this change solely to PDNA administration. No serious adverse events were documented; however, safety assessment was limited owing to missing data and retrospective ascertainment. These findings do not...

CONCLUSIONS: During the COVID-19 pandemic, Gram-negative pathogens continued to predominate among BSIs identified in ICUs, with an observed trend toward increased antimicrobial resistance, particularly among Enterobacterales species. Notably, prior antibiotic exposure was identified as the key independent determinant of MDR status in K. pneumoniae. Given the dynamic nature of pathogen distribution and resistance profiles in BSIs, consideration of local and period-specific resistance patterns in...

CONCLUSION: Higher CONUT scores were independently associated with increased risk of hospital mortality in sepsis patients. The CONUT score might serve as a valuable prognostic indicator for risk stratification in sepsis.

CONCLUSIONS: This exploratory analysis identified a possible interaction between baseline PENK and hydrocortisone treatment on kidney failure-free days. These findings require validation in independent and prospective studies.