CONCLUSIONS: LDAR independently predicts short-term mortality in critically ill patients with urosepsis, supplementing conventional severity scores. The parsimonious risk model showed moderate performance with acceptable cross-cohort generalizability.

CONCLUSIONS: This study describes the clinical and microbiological characteristics of pediatric P. sputorum-positive blood cultures at a single center and provides exploratory genomic data for two selected isolates. The recurrent carbapenem-discordant phenotype warrants careful antimicrobial susceptibility interpretation, and comprehensive molecular typing and functional studies are needed to define its genomic basis.

CONCLUSIONS AND RELEVANCE: In this prognostic study of 15 290 preterm infants, umbilical cord vessel qPCR identified twice as many infants who died from sepsis and 5 times as many who developed grade IV IVH compared with blood culture, suggesting that blood culture underestimates the clinical burden of neonatal sepsis.

Bloodstream infections (BSIs) are life-threatening disorders linked to substantial global mortality, and timely pathogen identification (ID) and antimicrobial susceptibility testing (AST) are indispensable for targeted clinical management. Blood culture (BC) remains the gold-standard diagnostic approach, but conventional workflows often lead to prolonged turnaround times (TAT) and delayed targeted therapy. This multicenter retrospective study aimed to evaluate the impact of the BC workflow...