This study developed a visual management approach for early fluid resuscitation in sepsis based on dynamic stratification of albumin, prealbumin, and transferrin. The retrospective analysis included 100 patients after propensity score matching. Measurements of the three proteins at T0, T6, T24, and T72 were considered together with fluid exposure, fluid responsiveness, and tissue perfusion indicators to derive a composite score and dynamic phenotypes; these results were then used to standardize...

CONCLUSION: Pediatric IMD remains an important cause of severe disease and mortality. The factors associated with severe outcome reflected three clinically relevant domains: neurological involvement, impaired peripheral perfusion, and vascular manifestations. Because these are simple clinical signs recognizable without laboratory testing, they may support early risk stratification and timely intervention, particularly in resource-limited settings.

CONCLUSIONS: JAK1 and GATA3 emerged as promising growth hormone-related candidate diagnostic biomarkers associated with immune heterogeneity in sepsis. Their combined signature may provide a useful framework for molecular stratification and warrants further experimental and clinical validation.

Sepsis‑associated acute kidney injury (S‑AKI) is a major cause of morbidity and mortality in critically ill patients, yet effective targeted therapies remain lacking due to an incomplete understanding of its pathogenesis. Ferroptosis, an iron‑dependent form of regulated cell death driven by lipid peroxidation, has recently been implicated in AKI, but the upstream regulators of this process in sepsis remain undefined. Here, we identify SIRT5, a mitochondrial NAD ⁺ ‑dependent desuccinylase, as a...