<b>Background and Objective:</b> Early-onset neonatal sepsis (EONS) is a major cause of neonatal morbidity and mortality globally, yet its early diagnosis remains challenging due to the limited availability of rapid, reliable biomarkers at the time of birth. This study aimed to analyze procalcitonin (PCT) and Interleukin-18 (IL-18) levels measured from umbilical cord blood as early diagnostic biomarkers for EONS. <b>Materials and Methods:</b> An observational case-control...

CONCLUSIONS: The LightGBM model incorporating five readily available coagulation and inflammatory markers accurately predicts in-hospital VTE in sepsis patients with T2DM, with robust discrimination, calibration, and clinical utility. SHAP-based interpretability enhances transparency and may facilitate personalized risk stratification and informed thromboprophylaxis decisions in this high-risk population.

CONCLUSION: In this study, we identified PLA2G2A as the candidate biomarker for diagnosis of sepsis in mice models through machine learning algorithms. And the data obtained may be helpful for subsequent research on sepsis pathogenesis.

CONCLUSIONS: In adult enterococcal BSI, hospital-acquired cases predominated. E. faecium was the dominant species, with higher ICU admission rates and a greater proportion of elderly patients than E. faecalis, although no statistically significant difference in mortality was observed. In the overall cohort and both subgroups, mortality was independently associated with disease severity, while no significant association was found for species.