CONCLUSION: While diagnostic accuracy at onset is comparable to CRP, the SII demonstrates potential as a practical dynamic indicator of therapeutic response in EOS. Its clinical application provides an objective biological signal that may help identify rapid responders, potentially supporting safely shortened antibiotic courses pending prospective validation.

CONCLUSIONS: This single-isolate genomic study is the first report of bla(CTX-M-15)-caryying MDR K. pneumoniae ST709-KL9 in India. Systematic and strategic large-scale genomic AMR surveillance is essential to understand the trafficking and contain the transmission of emerging pathogens in India.

CONCLUSIONS AND RELEVANCE: In septic shock with myocardial dysfunction, early hemodynamic responsiveness to dobutamine identified a subgroup with a more favorable clinical trajectory. Resting echocardiographic parameters did not identify responders. These findings are hypothesis-generating and require prospective confirmation.

CONCLUSIONS: In this cohort study of 29 647 adults presenting with community-onset presumed bacterial sepsis, presenting symptoms were associated with timing of antibiotic therapy. Even after adjusting for presenting symptoms, timely antibiotics remained associated with lower mortality. These findings suggest that proactive screening for sepsis among patients with less obvious clinical presentations may promote timely recognition and treatment.