Sepsis-induced myocardial injury is a frequent and life-threatening complication of sepsis, characterized by transient yet profound cardiac dysfunction that markedly worsens patient outcomes. Despite extensive investigation, the molecular mechanisms linking systemic inflammation to myocardial metabolic failure and cardiomyocyte loss remain incompletely understood. Emerging evidence indicates that nuclear factor-κB (NF-κB) signaling functions as more than a canonical inflammatory pathway in this...

CONCLUSION: We successfully developed a novel sepsis-associated brain dysfunction zebrafish larvae model. Based on its advantages of high throughput, rapidity, visualization, and facile gene edition, this model is expected to be beneficial for SAE drug discovery and disease mechanism exploration.

CONCLUSIONS: These findings support an association between host-protein testing for patients triggering ED sepsis alerts and the distribution of possible vs. unlikely sepsis cases. Multicenter clinical utility studies are warranted.

CONCLUSIONS: From 1999 to 2024, mortality involving both sepsis and respiratory failure increased substantially in the United States, with a pronounced surge during the COVID-19 pandemic and a subsequent decline. Higher burdens were observed among males, older adults, non-Hispanic Black individuals, residents of the South, and nonmetropolitan populations. Enhanced surveillance, vaccination and infection prevention, early intervention, and regional critical care resource allocation for these...