CONCLUSIONS: Higher plasma mitochondrial-associated protein abundance was associated with greater illness severity and worse short-term outcomes in suspected sepsis. These associations are hypothesis-generating, providing a first step toward understanding the role of mitochondrial dysfunction in sepsis severity.

CONCLUSION: The ESBL-KP NICU outbreak reveals gaps in hospital management, with ESBL-KP probably spreading due to high occupancy rate, poor IPC standards, and possibly by multiple simultaneous sources. Access to microbiology and the implementation of IPC practical interventions are critical to identifying and managing outbreaks in LIC.

INTRODUCTION: Extracorporeal circuit (EC) clotting remains a major challenge in continuous kidney replacement therapy (CKRT). While regional citrate anticoagulation (RCA) is recommended first-line, nafamostat mesylate (NM) offers an alternative with potential anti-inflammatory benefits. This trial aims to compare the effects of RCA, NM and their combination on EC lifespan during CKRT in critically ill acute kidney injury (AKI) patients with sepsis.

CONCLUSION: The NETs-mtROS axis represents an important pathway driving CD4^(+) T cell death in sepsis. Dual targeting of NETs and mitochondrial oxidative stress holds promising therapeutic potential for ameliorating sepsis-induced immunosuppression.